Publications

Operation Moonshot: rapid translation of a SARS-CoV-2 targeted peptide immunoaffinity liquid chromatography-tandem mass spectrometry test from research into routine clinical use

During 2020, the UK’s Department of Health and Social Care (DHSC) established the Moonshot programme to fund various diagnostic …
Jenny Hällqvist, Benjamin I. Nicholas, Alistair Bailey, et al
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Identification of neoantigens in esophageal adenocarcinoma

Esophageal adenocarcinoma (EAC) has a relatively poor long-term survival and limited treatment options. Promising targets for …
Ben Nicholas, Alistair Bailey, Katy J. McCann, Oliver Wood, Robert C. Walker, Robert Parker, Nicola Ternette, Tim Elliott, Tim J. Underwood, Peter Johnson, Paul Skipp
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Analysis of cell-specific peripheral blood biomarkers in severe allergic asthma identifies innate immune dysfunction

Our study sought cell type-specific gene signatures of severe allergic asthma in peripheral blood. We identified changes in monocytes …
Ben Nicholas, Jane Guo, Hyun-Hee Lee, Alistair Bailey, Rene de Waal Malefyt, Milenko Cicmil, Ratko Djukanovic
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Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands

CD8+ and CD4+ T cells provide cell-mediated cross-protection against multiple influenza strains by recognising epitopes bound as …
Ben Nicholas, Alistair Bailey, Karl J. Staples, Tom Wilkinson, Tim Elliott, Paul Skipp
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The differentiation state of the Schwann cell progenitor drives phenotypic variation between two contagious cancers

Contagious cancers are a rare pathogenic phenomenon in which cancer cells gain the ability to spread between genetically distinct …
Rachel Owen, Sri Ramarathinam, Alistair Bailey, Annalisa Gastaldello, Kathryn Hussey, Paul J.Skipp, Anthony W. Purcell, Hannah V. Siddle
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Characterization of the Class I MHC Peptidome Resulting From DNCB Exposure of HaCaT Cells

Skin sensitization following the covalent modification of proteins by low molecular weight chemicals (haptenation) is mediated by …
Alistair Bailey, Ben Nicholas, Rachel Darley, Erika Parkinson, Ying Teo, Maja Aleksic, Gavin Maxwell, Tim Elliott, Michael Ardern-Jones, Paul Skipp
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The immunopeptidomes of two transmissible cancers and their host have a common, dominant peptide motif

Transmissible cancers are malignant cells that can spread between individuals of a population, akin to both a parasite and a mobile …
Annalisa Gastaldello, Sri H. Ramarathinam, Alistair Bailey, Rachel Owen, Steven Turner, N. Kontouli, Tim Elliott, Paul Skipp, Anthony W. Purcell, Hannah V. Siddle
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Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility

T cell receptor (TCR) recognition of antigenic peptides bound and presented by class I major histocompatibility complex (MHC) proteins …
Cory M. Ayres, Esam T. Abualrous, Alistair Bailey, Christian Abraham, Lance M. Hellman, Steven A. Corcelli, Frank Noé, Tim Elliott, Brian M. Baker
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Direct evidence for conformational dynamics in major histocompatibility complex class I molecules

Major histocompatibility complex class I molecules (MHC I) help protect jawed vertebrates by binding and presenting immunogenic …
Andy van Hateren, Malcolm Anderson, Alistair Bailey, Jörn M. Werner, Paul Skipp, Tim Elliott
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Recent advances in Major Histocompatibility Complex (MHC) class I antigen presentation: Plastic MHC molecules and TAPBPR-mediated quality control

We have known since the late 1980s that the function of classical major histocompatibility complex (MHC) class I molecules is to bind …
Andy van Hateren, Alistair Bailey, Tim Elliott
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Selector function of MHC I molecules is determined by protein plasticity

The selection of peptides for presentation at the surface of most nucleated cells by major histocompatibility complex class I molecules …
Alistair Bailey, Neil Dalchau, Rachel Carter, Stephen Emmott, Andrew Phillips, Jörn M. Werner, Tim Elliott
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Two Polymorphisms Facilitate Differences in Plasticity between Two Chicken Major Histocompatibility Complex Class I Proteins

Major histocompatibility complex class I molecules (MHC I) present peptides to cytotoxic T-cells at the surface of almost all nucleated …
Alistair Bailey, Andy van Hateren, Tim Elliott, Jörn M. Werner
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A Mechanistic Basis for the Co-evolution of Chicken Tapasin and Major Histocompatibility Complex Class I (MHC I) Proteins

MHC class I molecules display peptides at the cell surface to cytotoxic T cells. The co-factor tapasin functions to ensure that MHC I …
Andy van Hateren, Rachel Carter, Alistair Bailey, Nasia Kontouli, Anthony P. Williams, Jim Kaufman, Tim Elliott
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Relating the structure, function and dynamics of the MHC Class I antigen presenting molecule

Alistair Bailey
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The relationship between protein dynamics and function for the MHC class I antigen presenting molecule

Tim Elliott, Alistair Bailey, Joern Werner, Rachel Carter, Andrew Phillips, Neil Dalchau, Martin Zacharias
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The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding

Major histocompatibility complex class I (MHC I) proteins protect the host from intracellular pathogens and cellular abnormalities …
A. Van Hateren, E. James, A. Bailey, A. Phillips, N. Dalchau, T. Elliott
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