Publications

Characterization of the Class I MHC Peptidome Resulting from DNCB Exposure of HaCaT Cells

Skin sensitization following the covalent modification of proteins by low molecular weight chemicals (haptenation) is mediated by …
Alistair Bailey, Ben Nicholas, Rachel Darley, Erika Parkinson, Ying Teo, Maja Aleksic, Gavin Maxwell, Tim Elliott, Michael Ardern-Jones, Paul Skipp
PDF DOI

Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility

T cell receptor (TCR) recognition of antigenic peptides bound and presented by class I major histocompatibility complex (MHC) proteins …
Cory M. Ayres, Esam T. Abualrous, Alistair Bailey, Christian Abraham, Lance M. Hellman, Steven A. Corcelli, Frank Noé, Tim Elliott, Brian M. Baker
PDF DOI

Direct evidence for conformational dynamics in major histocompatibility complex class I molecules

Major histocompatibility complex class I molecules (MHC I) help protect jawed vertebrates by binding and presenting immunogenic …
A. van Hateren, M. Anderson, A. Bailey, J. M. Werner, P. Skipp, T. Elliott
PDF DOI

Recent advances in Major Histocompatibility Complex class I antigen presentation: Plastic MHC molecules and TAPBPR-mediated quality control.

We have known since the late 1980s that the function of classical major histocompatibility complex (MHC) class I molecules is to bind …
Andy van Hateren, Alistair Bailey, Tim Elliott
DOI

Selector function of MHC I molecules is determined by protein plasticity

The selection of peptides for presentation at the surface of most nucleated cells by major histocompatibility complex class I molecules …
A. Bailey, N. Dalchau, R. Carter, S. Emmott, A. Phillips, J. M. Werner, T. Elliott
PDF DOI

Two Polymorphisms Facilitate Differences in Plasticity between Two Chicken Major Histocompatibility Complex Class I Proteins

Major histocompatibility complex class I molecules (MHC I) present peptides to cytotoxic T-cells at the surface of almost all nucleated …
Alistair Bailey, Andy van Hateren, Tim Elliott, Jörn M. Werner
PDF DOI

A mechanistic basis for the co-evolution of chicken tapasin and major histocompatibility complex class I (MHC I) proteins

MHC class I molecules display peptides at the cell surface to cytotoxic T cells. The co-factor tapasin functions to ensure that MHC I …
A. van Hateren, R. Carter, A. Bailey, N. Kontouli, A. P. Williams, J. Kaufman, T. Elliott
PDF DOI

The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding

Major histocompatibility complex class I (MHC I) proteins protect the host from intracellular pathogens and cellular abnormalities …
A. van Hateren, E. James, A. Bailey, A. Phillips, N. Dalchau, T. Elliott
PDF DOI