Dr. Alistair Bailey
class I antigen presentation; major histocompatibility complex; peptide loading; plasticity
Recent advances in Major Histocompatibility Complex class I antigen presentation: Plastic MHC molecules and TAPBPR-mediated quality control.
We have known since the late 1980s that the function of classical major histocompatibility complex (MHC) class I molecules is to bind peptides and display them at the cell surface to cytotoxic T cells. Recognition by these sentinels of the immune …